Open AccessPotency of Phytochemicals from Guava (Psidium guajava) Seeds against Escherichia coli to Cure Diarrhoea: An in silico Analysis
Author(s) -
Barsha Nayak,
Lopita Mishra,
Bibhu Prasad Mishra,
Srimay Pradhan,
Bhagyeswari Behera,
Mukundjee Pandey
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i930538
Subject(s) - psidium , escherichia coli , potency , phytochemical , docking (animal) , biochemistry , chemistry , biology , traditional medicine , pharmacology , botany , medicine , in vitro , veterinary medicine , gene
Machine learning to deep learning is the enduring upgrading in the pharmaceutical research field. Phytochemicals from Psidium guajava plant extract are traditionally used to cure Diarrhoea. The causative agent of the disease is Escherichia coli. To identify the secondary metabolites (ligand) which is the main responsive compound that have the capacity to inhibit the growth of microorganism was carried by molecular docking method “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Heptadecanoic acid can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.