Open AccessMoringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid
Author(s) -
Sonali Suchismita Behera,
Seema Suvadarshini,
Ipsita Aparajita Mohapatra,
Sonali Dash,
Amit Kumar Sahoo,
Soumyashree Nayak,
Meenakshee Mohanty,
Punya Prateek Majhi,
Srimay Pradhan
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i930534
Subject(s) - typhoid fever , salmonella typhi , moringa , salmonella , reductase , traditional medicine , microbiology and biotechnology , enzyme , biology , medicine , bacteria , biochemistry , escherichia coli , genetics , gene
Phytochemicals from Moringa oleifera plant extract can cure Typhoid. It is caused by Salmonella typhi. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 4,8,12,16-tetramethylheptadecan-4-olide can effectively deactivate the 2-hydroxy-3-oxopropionate reductase enzyme thereby interrupting the life cycle of the organism.