Open AccessEclipta alba L. Derived Phytochemicals against Escherichia coli Causing Diarrhea
Author(s) -
K. R. Beula Rani,
A.M. Mohanty,
Sagarika Parida,
Manisha Mohanty,
Shovan Kumar Sahu,
Sasmita Kumari Nayak,
Sutapa Mohanty
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i730519
Subject(s) - escherichia coli , diarrhea , alcohol dehydrogenase , organism , escherichia , microbiology and biotechnology , docking (animal) , biology , chemistry , enzyme , biochemistry , medicine , veterinary medicine , genetics , gene
Phytochemicals from Eclipta alba L. plant extract are traditionally used to cure Diarrhea. It is caused by Escherichia coli. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Pentadecanone can effectively deactivate the alcohol dehydrogenase enzyme (protein database code 4GKV) thereby interrupting the life cycle of the organism.