Open AccessMyristica fragrans Derived Phytochemicals against Shikimate Dehydrogenase of E. coli Causing Diarrhea
Author(s) -
Sunanya Das,
Debasmita Das,
Ashrumochan Nayak,
Sonali Dash,
Dipankar Bhattacharyay
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i630502
Subject(s) - phytochemical , eugenol , traditional medicine , diarrhea , myristica fragrans , biology , enzyme , biochemistry , chemistry , botany , medicine , organic chemistry
Medicinal plants play a key role in human health care. Phytochemicals can be derived from different parts of plants. Different medicinal plants and their phytoextracts have shown anti-microbial action. Phytochemicals from Myristica fragrans plant extract are traditionally used to cure Diarrhea. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Eugenol can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.