Open AccessEndocrine Markers of Fertility Potential in Reproductive Age Women with Idiopathic Hyperprolactinemia
Author(s) -
Alina Atalyan,
Leonid Fedorovich Shelokhov,
Л. И. Колесникова
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i2330790
Subject(s) - prolactin , endocrine system , medicine , hormone , fertility , endocrinology , testosterone (patch) , follicle stimulating hormone , physiology , triiodothyronine , infertility , thyroid function , pregnancy , luteinizing hormone , biology , population , environmental health , genetics
Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder.
Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia.
Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP. All women underwent a standard history taking, clinical examinations. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method.
Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and free triiodothyronine and a decrease of estradiol and cortisol when compared with fertile patients with HP and Healthy patients.
Conclusion: The better glucocorticoid and ovarian function of fertile women with HP supposed to be an essential issue in their reproductive ability.