Open AccessComparison of Anxiolytic Drugs of Diazepam and Zolpidem in Patients Undergoing Extraction
Author(s) -
A. Deepak,
Dhanraj Ganapathy,
Visalakshi Ramanathan
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i1830701
Subject(s) - zolpidem , sedation , diazepam , anxiolytic , anxiety , hamilton anxiety rating scale , medicine , anesthesia , benzodiazepine , pharmacology , psychiatry , insomnia , receptor
Anxiolytic drugs are a class of drugs that reduce the anxiety levels in the individuals by nonspecifically binding to the GABAα located throughout the central nervous system. The aim of this study was to compare the anxiolytic effects of diazepam and Zolpidem in patients undergoing extraction. This was a cross-sectional study conducted at a university setting, with a sample size of 100 patients, of the age group 25-45 years. 50 patients were administered with Tab. Diazepam and 50 patients with Tab. Zolpidem one hour before the surgical procedure. The Hamilton Anxiety Rating Scale (HAM-A Scale) was used to record the patient's anxiety levels before and during the extraction procedure. These data were then recorded in MS Excel Sheet and imported to SPSS for statistical analysis. From this study, it can be seen that most of the patients were females and mainly between the age group 25-35 years. Diazepam had significantly lesser post sedation anxiety levels in comparison with its post sedation levels than zolpidem with, a statistically significant difference (p<0.001). Therefore, it can be concluded that diazepam had better post sedation effects than zolpidem in patients undergoing extraction as patients presented with lesser severity in their anxiety levels.