Open AccessAn Observational Study on the Mode of Action of Ferulic Acid on Common Dental Pathogens – An in Silico Approach
Author(s) -
R. Nivethitha,
A. S. Smiline Girija,
Vijayashree Priyadharsini Jayaseelan
Publication year - 2020
Publication title -
journal of pharmaceutical research international
Language(s) - English
Resource type - Journals
ISSN - 2456-9119
DOI - 10.9734/jpri/2020/v32i1830684
Subject(s) - tannerella forsythia , treponema denticola , virulence , in silico , ferulic acid , microbiology and biotechnology , porphyromonas gingivalis , streptococcus mutans , biology , enterococcus faecalis , enterococcus hirae , forsythia , enterococcus , biochemistry , bacteria , staphylococcus aureus , genetics , medicine , honeysuckle , alternative medicine , pathology , traditional chinese medicine , gene , antibiotics
In this study, the functional and virulent classes of proteins that are targeted by ferulic acid are identified from the most common dental pathogens like Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Streptococcus mutans and Enterococcus faecalis by an in silico approach. The target proteins were selected using STITCH tool, the functional class of proteins was predicted using VICMpred. The predicted virulent proteins were further subjected to BepiPred analysis, which returned the number of peptide epitopes present in the protein. Further, the subcellular location of the proteins was confirmed by the PSORTb tool. Ferulic acid was found to interact with virulence factors such as dihydrolipoyl dehydrogenase of Streptococcus mutans, putative lipoprotein of P. gingivalis and phosphogluconate dehydrogenase of T. forsythia. The findings of the study emphasize the promising interactive role of ferulic acid and their potential protein targets in common oro-dental pathogens which requires further experimental validation in-vivo and in-vitro.