Open AccessEvaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo
Author(s) -
D. M. Abo Anber,
Dareen Abdelaziz Mohammed Ali,
Rania Ahmed ElTatawy,
Lamia Hamouda Elgarhy
Publication year - 2021
Publication title -
journal of advances in medicine and medical research
Language(s) - English
Resource type - Journals
ISSN - 2456-8899
DOI - 10.9734/jammr/2021/v33i630856
Subject(s) - vitiligo , medicine , fluorouracil , dermatology , surgery , treatment modality , side effect (computer science) , chemotherapy , computer science , programming language
Background: Vitiligo is a chronic cutaneous disease characterized by depigmented patches that leave psychological impact on the patients. New treatment modalities have been developed to improve the results vitiligo with less side effects.
Objective: To evaluate intralesional injection of 5-fluorouracil in treatment of vitiligo.
Patients and Methods: The study included 20 localized stable vitiligo patients. Each patient was treated with intralesional injection of 5-fluorouracil every 2 weeks for 3 sessions followed by narrow band sessions twice weekly for 3 months.
Results: There was statistically significant repigmentation after treatment with intralesional 5-FU (mean of 50.30 ± 34.60, P value =0.001 Wilcoxon signed ranks test between before and after). 55% of patients showed >50% repigmentation. after 3 months therapy. Side effects were minimal and transient.
Conclusion: Intralesional injection of 5-FU is safe and effective in the treatment of vitiligo.