Open AccessAntiplatelet Effect of Aspirin in Ischemic Stroke: A Hospital-based Study
Author(s) -
Masaraf Hussain,
Yookarin Khonglah,
Shailesh Sharma,
Baia Synmon,
Yasmeen Hynniewta
Publication year - 2021
Publication title -
journal of advances in medicine and medical research
Language(s) - English
Resource type - Journals
ISSN - 2456-8899
DOI - 10.9734/jammr/2021/v33i2231175
Subject(s) - aspirin , medicine , stroke (engine) , dyslipidemia , diabetes mellitus , incidence (geometry) , antiplatelet drug , ischemic stroke , population , ischemia , clopidogrel , disease , endocrinology , mechanical engineering , physics , optics , engineering , environmental health
Aspirin is widely used for the treatment of stroke. Therefore aspirin resistance can lead to a significant increase in the burden of stroke. Platelet aggregation studies can evaluate platelet function, and this may help to detect anti-platelet resistance.
Methods: This is a hospital-based study of the antiplatelet effect of aspirin in ischemic stroke, during a duration of one year.
All first-time ischemic stroke patients >18 years of age were included. Platelet aggregometry test was done by LTA (Light transmission optical aggregometer), after starting the patients on oral aspirin.
Results: A total of 113 ischemic stroke patients were included for the antiplatelet effect of the aspirin study. Aspirin resistance was found in 18.58% of patients. Patients with aspirin resistance had higher mortality, and less improvement on follow-up, as compared to aspirin-sensitive patients. They had more incidence of smoking, alcohol abuse, diabetes mellitus, and dyslipidemia, as compared to the aspirin-sensitive group. The results reveal that there is a non-statistically significant trend in both mortality and prognosis between the two study groups compared: aspirin-resistant versus aspirin-sensitive patients.
Conclusion: Aspirin resistance can lead to loss of functional improvement and more mortality than aspirin-sensitive patients. However, further study for drug interactions, adequate risk factor control, the genetic profile of the population is needed, to come to a definite conclusion.