Open AccessEffect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study
Author(s) -
Wasim Ahmad Wani,
Sheeraz A. Dar,
Khalid M. Kawosa,
Mudasir Nazir,
Irshad Ahmad,
Asif Ahmed
Publication year - 2020
Publication title -
journal of advances in medicine and medical research
Language(s) - English
Resource type - Journals
ISSN - 2456-8899
DOI - 10.9734/jammr/2020/v32i630430
Subject(s) - medicine , eosinophil , immunoglobulin e , budesonide , asthma , budesonide/formoterol , randomized controlled trial , eosinophil cationic protein , immunology , formoterol , gastroenterology , antibody
Background: Asthma is a chronic inflammatory condition of lung airways resulting in episodic airflow obstruction.
Aims: The main objective of this study is to find the effect of antiasthma medication on serum IgE levels and blood eosinophil count.
Study Design: This randomized controlled trial study was performed in children aged 6-15 years of age, with clinically stable and moderate persistent asthma.
Results: The findings of this study indicate both group (Budesonide/formoterol group and budesonide group) patients experienced a significant decrease in serum IgE levels and blood eosinophil counts over the study period. However, the difference in two groups was not statistically significant.
Conclusions: Inhaled steroids are effective in controlling systemic inflammation in asthma as evidenced by a decrease in IgE levels and eosinophil counts. However addition of LABA doesn’t have any additive effect.