Open AccessDiagnostic Value of Serum Leptin Level in Critically Ill Septic Child
Author(s) -
Asmaa A. Abo El Yazeed,
Ahmed Ibrahim Harkan,
Amira Youssef Ahmed,
Ahmed Abo Elezz
Publication year - 2020
Publication title -
journal of advances in medicine and medical research
Language(s) - English
Resource type - Journals
ISSN - 2456-8899
DOI - 10.9734/jammr/2020/v32i2430760
Subject(s) - medicine , sepsis , leptin , critically ill , pediatric intensive care unit , intensive care unit , systemic inflammatory response syndrome , intensive care medicine , gastroenterology , obesity
Diagnosis of sepsis is important to reduce morbidity and mortality. Leptin is an important immunoregulatory hormone that enhances a number of immune responses in sepsis.
Objective: to assess serum leptin in diagnosing sepsis in critically ill pediatric patients.
Subjects and Methods: This study was carried out on 50 children divided into a case group included 40 critically ill patients initially sepsis free and fulfilling 2 of 4 criteria of SIRS admitted to the Pediatric Intensive Care Unit, children hospital, Tanta university and a control group included 10 apparently healthy children. According to the presence or absence of infection, our patients were classified into SIRS group and sepsis group. For all studied patients; serum leptin, CRP and others indicators of sepsis were measured at admission and 72h later, while were measured one time only for control group.
Results: patients who developed sepsis had significantly higher serum leptin levels than those of the control group and SIRS (33.9 ± 20.8 vs. 1.9 ± 0.4, 21.5+ 10.1 respectively, p>0.05).
Conclusion: Serum leptin may have a role in early diagnosis of sepsis.