Open AccessWhen Oxygen Can Be Toxic? A Mini Review
Author(s) -
Ali M. Elshafei
Publication year - 2020
Publication title -
journal of applied life sciences international
Language(s) - English
Resource type - Journals
ISSN - 2394-1103
DOI - 10.9734/jalsi/2020/v23i730171
Subject(s) - superoxide , reactive oxygen species , chemistry , oxygen , radical , hydrogen peroxide , electron transport chain , biochemistry , biophysics , photochemistry , biology , enzyme , organic chemistry
No one within the past later a long time had in intellect that the oxygen we breathe that contributes to sparing the lives of millions of patients and the most component of life has no harmful impacts on the body. Oxygen and water are the soul of living beings in common but beneath certain conditions such as weak immune status and lack of the body's ability to excrete natural antioxidants happens that the oxygen atom responds as a receptor for electrons, since its structure within the case of electronic soundness has two electrons that are not bound and as a result of progressive responses that create a few intermediate compounds. (Such as hydroxyl radical (•OH), hydrogen peroxide (H2O2) and superoxide anion (•O-2) that are hurtful to human’ organs and influence the extraordinary degree of cell division process and the physiological activities that it performs since it could be a capable oxidizer. These reactive atoms and free radicals inferred from atomic oxygen are called Reactive Oxygen Species (ROS). In spite of the fact that ROS play a key part as a flag-bearer in ordinary cell flag transduction and cell cycling, they have long been known to be a component of the immune reaction of safe cells to microbial invasion. ROS are created as byproducts during the mitochondrial electron transport of aerobic respiration or by oxido/reductase proteins and metal-catalyzed oxidation. The primary step in ROS generation is the reduction of atomic oxygen (O2) to anion superoxide (•O-2), is the antecedent of other responsive species. For this reason, the significance of normal cancer prevention agents has gotten to be vital to urge freed of the poisonous quality of ROS and particular antioxidant supplement ought to be given to improve the diet. Among the well-known antioxidants and cancer prevention agents are glutathione, vitamins C and D as well as enzymes such as, superoxide dismutase, catalase and peroxidase which contribute successfully to the disposal of these oxidizing substances.