Open AccessA Review on Neurotoxins from Clostridium botulinum against Neuro-muscular Disorders
Author(s) -
Sravani Nalapur,
Rangarao Ambati
Publication year - 2021
Publication title -
journal of advances in biology and biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2394-1081
DOI - 10.9734/jabb/2021/v24i730223
Subject(s) - clostridium botulinum , botulism , botulinum toxin , neurotoxin , muscular dystrophy , botulinum neurotoxin , medicine , biology , toxin , neuroscience , microbiology and biotechnology
Neuro-muscular disorders cause a series of serious complications in the human body, where some lead to considerable morbidity and mortality ocassionally. Neurological diseases result in dystrophy, inhibited growth, etc. This present review aimed to emphasize the employment of neurotoxins against neuro degenerative disorders. The source of neurotoxins includes botulinum (Clostridium botulinum), snakes like Vespa orientalis and some medically important arthropods like hornets and spiders. The review not only describes the potential of the neurotoxins in the treatment but also elucidates the mechanism of action of lethal toxins like botulinum. Safety and dosage regimens of various toxins with the help of proven study data would aid in endorsing researchers for further research on toxins making them more superior targeted drugs.