Open AccessA New Flame AAS Application for Magnesium Determination in Solid Pharmaceutical Preparations as an Active Ingredient and an Excipient
Author(s) -
Abdullah Sbahi,
Wassim Abdelwahed,
Amir Alhaj Sakur
Publication year - 2020
Publication title -
international research journal of pure and applied chemistry
Language(s) - English
Resource type - Journals
ISSN - 2231-3443
DOI - 10.9734/irjpac/2020/v21i2330305
Subject(s) - magnesium stearate , chemistry , magnesium , excipient , talc , chromatography , active ingredient , atomic absorption spectroscopy , dosage form , ingredient , metallurgy , organic chemistry , materials science , food science , pharmacology , medicine , physics , quantum mechanics
Objective: A new application of Atomic Absorption Spectroscopy (AAS) has been carried out to determine magnesium in its solid preparations (effervescent and uncoated compressed tablets) as an active ingredient and/or excipient.
Methodology: The linear range of magnesium was determined. A sample of magnesium effervescent tablets was analyzed. Magnesium stearate concentration was also indirectly determined in commercial paracetamol tablets using two digestion methods. Finally, a sample of drug-free tablets (only contain excipients) was analyzed to study the effect of talc on total magnesium content of the sample.
Results: Linear range was observed in concentrations between 0.08-0.40 ug/mL of magnesium. Effervescent tablets samples were recovered in the range between 98.66-103.00% which indicates that the product meets specifications. For paracetamol tablets, the content of magnesium stearate was in average of 0.2% and there is no differences between the two digestion methods (t=0.454). Our work on the drug-free sample proved a significant increase of magnesium concentrations in the presence of talc.
Conclusion: The AAS method is a simple and rapid technique that can be employed for the simultaneous estimation of magnesium in in-process and final products analyses.