Open AccessEmerging Threat of Salmonella typhimurium in Extraintestinal Infections: Cases from a Tertiary Care Hospital in North India
Author(s) -
Anuj Jain,
Anurag Pandey,
Nirupama Chatterjee,
Santosh Kumar Giri,
Saurabh Anand,
Ragesh Radhakrishnan Nair,
Pawan Kumar Singh,
Namita Jaggi
Publication year - 2020
Publication title -
international journal of tropical disease and health
Language(s) - English
Resource type - Journals
ISSN - 2278-1005
DOI - 10.9734/ijtdh/2020/v41i430269
Subject(s) - salmonella , serotype , flagellin , salmonella enterica , typhoid fever , medicine , antibiotics , meningitis , microbiology and biotechnology , cephalosporin , biology , immunology , bacteria , pediatrics , genetics , receptor
Purpose: Infections due to invasive non-typhoid salmonella can be dangerous and fatal. The mode of infection and the severity varies from the typhoidal fevers. It is important to find the association between clinical features and the infecting serovar to understand the pathophysiology and course of treatment.
Methods: In the present study, extra-intestinal specimens (blood, cerebrospinal fluid and pus) from three patients suffering from septicaemia, meningitis and osteomyelitis were received. Micro-biological and biochemical test for species identification and antibiotic susceptibility was done as per standard protocol. Further, PCR based amplification and sequencing of a portion of the flagellin gene (FliC) was done to confirm the serovar.
Results: Salmonella enterica was identified from all the three by microbiological and biochemical examination.The sequence of the Flic gene confirmed the serovar to be S. typhimurium. All the patients were treated successfully for the infection by appropriate antibiotic therapy.
Conclusion: The study highlights that serovar Typhimurium is common in invasive non-typhoidal salmonellosis and its pathophysiology and virulence factors expression should be understood in various organ types for better treatment options and outcomes.