Open AccessChemical Constituents from Wood of Zanthoxylum rigidum Hum. and Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activities
Author(s) -
Carlos Henrique Corrêa dos Santos,
Mayara C. Sousa,
Paulo Teixeira de Sousa,
Tereza Auxiliadora Nascimento Ribeiro,
Marco Jacinto,
Virgínia C. Paulino Silva
Publication year - 2021
Publication title -
european journal of medicinal plants
Language(s) - English
Resource type - Journals
ISSN - 2231-0894
DOI - 10.9734/ejmp/2021/v32i530390
Subject(s) - zanthoxylum , chemistry , lupeol , rutaceae , traditional medicine , leishmania braziliensis , stigmasterol , quercetin , clusiaceae , sesamin , botany , biology , leishmaniasis , cutaneous leishmaniasis , food science , biochemistry , chromatography , medicine , immunology , antioxidant
In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).