Open Access3D Series Metal Complexes Containing Schiff Base Ligand with 2,2'-Bipyridine: Synthesis, Characterization and Assessment of Antifungal Activity
Author(s) -
B. Kpomah,
U. Ugbune,
T. E. Idu
Publication year - 2021
Publication title -
chemical science international journal
Language(s) - English
Resource type - Journals
ISSN - 2456-706X
DOI - 10.9734/csji/2021/v30i1030258
Subject(s) - denticity , chemistry , semicarbazone , aspergillus niger , metal ions in aqueous solution , ligand (biochemistry) , metal , zinc , schiff base , fourier transform infrared spectroscopy , bipyridine , inorganic chemistry , stereochemistry , organic chemistry , biochemistry , crystal structure , physics , receptor , quantum mechanics
The rapid increase in the number of multidrug-resistant of most pathogenic organisms is fast becoming a global concern, thus, the discovery of novel active pharmacological compounds against new targets is a matter of urgency. The incorporation of metal ions into organic ligands has introduced metal-organic drugs framework with synergistic effects for novel applications in the biological system. In this research work, metal(II) chloride complexes of copper, nickel and zinc containing methylphenylketone thiosemicarbazone (MPK-TSC) with 2,2’-bipyridine (bipy) were synthesized; they were further characterized by satisfactory microelemental analysis, Fourier Transform InfraRed (FTIR) spectra as well as electronic spectra study. The complexes are proposed to have the formulae [L1ML2(Cl2)] where M=metal ion, L1=methylphenylketone thiosemicarbazone L2=2,2’-bipyridine. The complexes are of 1:2 (metal:ligand) stoichiometry and non-electrolytes in solution, the bidentate nature of the two ligands was evident from the FTIR spectra. The compounds were screened for their antifungal activity against four pathogenic fungi: Aspergillus niger, Penicillium Species, Rizopus and Candida albicans using disc diffusion method. The activities of the complexes have been found to be greater than those of the metal salts and the uncoordinated ligands.