Open AccessEffect of Pre and Post Infection Administration of Zinc and Selenium on some Biochemical indices in Wistar Rats infected with Trypanosoma brucei
Author(s) -
T. Tese,
Kola Matthew Anigo,
Alice Jonah,
M. A. Kugama,
T. Andrew,
Janet Larai Ibrahim,
Raymond Arumona,
William Denbon Genesis Chinten
Publication year - 2021
Publication title -
biotechnology journal international
Language(s) - English
Resource type - Journals
ISSN - 2456-7051
DOI - 10.9734/bji/2021/v25i230138
Subject(s) - trypanosoma brucei , creatinine , selenium , alkaline phosphatase , zinc , oral administration , urea , biology , medicine , pharmacology , chemistry , biochemistry , enzyme , organic chemistry , gene
Aims: The effect of pre and post-infection administration of zinc and selenium on Trypanosoma brucei brucei infection in wistar rats on some biochemical parameters were investigated.
Study Design: The study was designed to evaluate the effect of pre and post infection administration of zinc and selenium on Trypanosoma brucei brucei infection in wistar rats.
Place and Duration of Study: The study was conducted at the Nigerian Institute for Trypanosomiasis Research (NITR), Kaduna and Department of Biochemistry, Ahmadu Bello University (ABU), Zaria, between January 2014 to March 2014.
Methodology: Fifty four (54) wistar rats were divided into nine groups of six (6) rats each. Groups III-IX were infected intraperitoneally with 1x103parasite load. Animals in group III were infected but untreated while the infected/treated groups received prophylactic (IV, V and VI) and therapeutic (VII, VIII and IX) treatment with zinc and selenium 50mg/kg and 10mg/kg body weight respectively.
Results: Results obtained showed that serum alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) activities in the infected-untreated control group were significantly different (P 0.05) decrease. On the other hand, a significant (P 0.05) difference in direct bilirubin was recorded in infected treated group compared to infected untreated and normal control.
Conclusion: It was concluded that administration of zinc and selenium ameliorate the infection-induced biochemical changes in tissues and organs associated with Trypanosoma brucei brucei infection in Wistar rats.