Open AccessFormulation and Characterization of Rutin Loaded Chitosan Nanoparticles
Author(s) -
M. Ganga Raju,
M. Srivani,
N. V. L. Suvarchala Reddy,
G. Shanthi Priya
Publication year - 2022
Publication title -
asian journal of research in medical and pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 2457-0745
DOI - 10.9734/ajrimps/2022/v11i130180
Subject(s) - rutin , bioavailability , zeta potential , particle size , nanoparticle , chitosan , solubility , drug delivery , pharmaceutics , chemistry , materials science , chromatography , dissolution , chemical engineering , nanotechnology , antioxidant , organic chemistry , pharmacology , medicine , engineering
New drug delivery technologies are transforming drug discovery and development, as well as establishing research and development-focused pharmaceutical firms that are accelerating global progress. The bioactive rutin molecule is used in a wide range of food and medicinal goods. Its limited bioavailability and poor water solubility are major issues. Rutin is a polyphenolic natural compound with antibacterial, anticancer, antioxidant, chemopreventive, and anti-inflammatory activities. However, no research has been published to yet to improve its bioavailability and efficacy. As a result, an attempt was made in this study to load rutin into a nanoparticlulate system in order to improve its bioavailability and efficacy. Six formulations (F1-F6) of nanoparticles were prepared by solvent evaporation technique and were evaluated for particle size and shape using Zeta Sizer, Scanning Electron Microscopy (SEM) and Fourier Transform Infra-Red (FT-IR) Spectroscopy. The optimized formulation was further subjected to in vitro evaluation. Practical percent yield, drug entrapment efficiency and In vitro drug release were evaluated. Out of various formulations F1 have shown best results in particle size 80.71 (1-100 nm), particle shape (spherical nanoparticles with a smoothed surface), average size distribution (105.0), zeta potential (-20.6) percentage yield (70.83), drug entrapment efficiency (83.6%) and drug loading (95%). Pure rutin showed incomplete dissolution of 47.69% in 330 min while Rutin loaded nanoparticles gave 94.75% release in 330 min. It is obvious from the foregoing that rutin chitosan nanoparticles were used as a novel drug delivery technology to improve therapeutic efficacy and sustained release features while overcoming issues such as poor solubility and limited bioavailability.