Open AccessBisphenol a Exposure Causes Increased Oxidation of Low Density Lipoprotein (LDL) and Its Abduct in Rats
Author(s) -
Chinenye E. Oguazu,
F. C. Ezeonu,
Charles C. Dike,
Charles German Ikimi
Publication year - 2021
Publication title -
asian journal of research in biochemistry
Language(s) - English
Resource type - Journals
ISSN - 2582-0516
DOI - 10.9734/ajrb/2021/v9i230195
Subject(s) - chemistry , low density lipoprotein , bisphenol a , malondialdehyde , oxidative damage , medicine , endocrinology , lipoprotein , cholesterol , oxidative stress , biochemistry , organic chemistry , epoxy
Background and Objectives: Living organisms are exposed to oxidant agents constantly from both endogenous and exogenous sources. One of such oxidant agent is Bisphenol A (BPA) and its exposure is capable to modify biomolecules and induce damages. Bisphenol A (BPA) is a contaminant with increasing exposure. It exerts toxic effects on cells. This study investigates the possibility of BPA exposure on Low Density Lipoprotein (LDL) perturbations at prevailing low exposure doses in female albino Wistar rats, following exposure for the period of three (3) month. Materials and Methods: Total 12 groups were formed; out of which 11 experimental groups, each containing 10non-pregnant female rats were administered; 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 1 mg of BPA/kgbw/day. To the 12th control group was given water. Blood was collected from animals at the end of every week of the study and serum sample specimens analyzed by routine diagnostic procedures for oxidized LDL such as malondialdehyde modified- LDL (MDA-LDL), oxidized phospholipids LDL (OX-PL LDL), N (epsilon) (carboxymethyl) lysine-modified-LDL (CML LDL) and 4-hydroxynonenal-LDL (HNE-LDL) using Autochemical Analyzer.
Results: Significantly increased concentrations of serum oxidized LDL such as MDA-LDL, OX-PL LDL, CML LDL and HNE-LDL were observed at all concentrations of BPA exposure.
Conclusion: Bisphenol A alters oxidized LDL such as MDA-LDL, OX-PL LDL, CML LDL and HNE-LDL balance and causes disturbance of internal oxidative statues.