Open AccessRegeneration of Pancreas Β-Cells in Alloxan-Induced Diabetes Rats Treated with Aqueous Seed Extract of Syzygium aromaticum: A Preliminary Study
Author(s) -
Azeemat Titilola Abdulazeez,
Kehinde H. Bello,
Mutiu A. Alabi,
Fatai A. Kareem,
Janet F. Adeegbe
Publication year - 2021
Publication title -
asian journal of research in biochemistry
Language(s) - English
Resource type - Journals
ISSN - 2582-0516
DOI - 10.9734/ajrb/2021/v9i130191
Subject(s) - syzygium , alloxan , saline , diabetes mellitus , aqueous extract , medicine , traditional medicine , pancreas , endocrinology
Aim: The present study was conducted to investigate the preventive/curative effect of aqueous seed extract Syzygium aromaticum in alloxan-induced diabetes in rats.
Study Design: Twenty Wistar rats were randomly divided into four groups. The rst group served as a control (received 1 ml of normal saline). The second group served as Diabetic control (received 1 ml of normal saline). The third group served as test 1 (pre-treated with 500 mg/kg body weight (b.w.) of aqueous Syzygium aromaticum seeds extract for seven days prior to diabetic induction and post-treated with aqueous seeds extract of Syzygium aromaticum after diabetic induction) and the fourth group served as test 2 (post-treated with 500 mg/kg b.w. of aqueous seed extract of Syzygium aromaticum after diabetic induction) in a daily oral dose for 14 days.
Results: Treatment of rats with aqueous seed extract of Syzygium aromaticum in a daily dose of 500 mg/kg significantly mitigates the induced changes in the glucose and lipid prole parameters. Histopathological examination of the pancreas showed the destruction of β-cells in the diabetic control group and recovery of damaged tissues when treated with 500 mg/kg b.w. of aqueous seeds extract of Syzygium aromaticum.
Conclusion: The present study suggests that aqueous seed extract S. aromaticum seeds extract at a dose of 500 mg/kg body weight brings about regeneration of the B-cells of the pancreas and signicant benecial effects in various physiological parameters in alloxan-induced diabetes.