Open AccessCongenital Coagulation Factor XIII Deficiency Revealed by Convulsion: A Case Report
Author(s) -
Nadia Mebrouk,
T. Benouachane,
L. Chtouki,
F. Jabourik,
A. Bentahila
Publication year - 2021
Publication title -
asian journal of pediatric research
Language(s) - English
Resource type - Journals
ISSN - 2582-2950
DOI - 10.9734/ajpr/2021/v6i130187
Subject(s) - factor xiii , medicine , fresh frozen plasma , coagulation disorder , coagulation , fibrinogen , coagulopathy , factor xi , intracerebral hemorrhage , convulsion , partial thromboplastin time , risk factor , coagulation testing , factor xiii deficiency , surgery , pediatrics , anesthesia , gastroenterology , epilepsy , psychiatry , platelet , subarachnoid hemorrhage
Factor XIII deficiency is a rare inherited disease, with a particularly high risk of intracerebral hemorrhage. We report the case of a newborn who was suspected to have a coagulation disorder at birth, due to an intracerebral hemorrhage. A quantitative dosage of factor XIII was requested but the usual coagulation tests (thromboplastin, thrombokinase, fibrinogen) were normal. Because of unavailability of specific treatment with factor XIII concentrate, the patient was treated with fresh frozen plasma. The initial dose was for normalizing factor XIII; subsequent monthly doses were designed for preventing the occurrence of serious bleeding.