Open AccessConcurrent Sickle Cell Anemia and Diabetes Mellitus with Ketosis in a Libyan Toddler: First National Report and Youngest Case Study
Author(s) -
Moftah H. Alhagamhmad,
Alia Alhassony,
Abdulhamid,
Aisha Elarwah,
Shirin Alougly,
Suliman Elbrgathy,
Nuri M. Shembesh,
Emhemed Mousa
Publication year - 2020
Publication title -
asian journal of pediatric research
Language(s) - English
Resource type - Journals
ISSN - 2582-2950
DOI - 10.9734/ajpr/2020/v3i430134
Subject(s) - medicine , toddler , pediatrics , polydipsia , polyuria , diabetic ketoacidosis , diabetes mellitus , ketonuria , sickle cell anemia , glycosuria , anemia , ketosis , hypophosphatemia , endocrinology , disease , psychology , developmental psychology
Sickle cell Anemia (SCA) is a common inherited haemoglobinopathy resulting from a single-point mutation on the β-globin subunit of hemoglobin. It is a chronic condition with multi-system involvement. Growth delay, osteopenia and hypogonadism are common endocrine dysfunctions with a lower frequency of impaired glucose tolerance. However, there is an association between SCA and diabetes mellitus (DM), though it is very rare. Certainly, there are only a few published reports worldwide outlined this uncommon combination. In this report, we will present the first Libyan case study of co-existence of the two diseases in a-16-month-old male toddler recording the youngest patient diagnosed with such a rare combination. The child, who was diagnosed earlier with SCA, brought with concerns of frequent changing nappies (polyuria) and excessive thirst (polydipsia) for 2 weeks that worsened recently. On admission, the toddler was distressed, lethargic and his lab parameters showed hyperglycemia, ketonuria, glycosuria and acidosis, a diagnosis of diabetic ketoacidosis (DKA) on the background of SCA therefore was made. Further observations are warranted to properly guide about the diagnosis and management of such rare cases.