Open AccessControlled Catalytic Reduction in Synthesising Pure Tetrahydrocurcumin
Author(s) -
Chandra Sekhara Rao Nethinti,
Dhanraj T. S. S. Sundaram,
Sudhir Kumar,
Sreenivasulu Boju,
Raghu Babu Korupolu,
Annapurowduri,
Uttam Kumar Ray
Publication year - 2022
Publication title -
asian journal of chemical sciences
Language(s) - English
Resource type - Journals
ISSN - 2456-7795
DOI - 10.9734/ajocs/2022/v11i219120
Subject(s) - catalysis , curcumin , high performance liquid chromatography , chemistry , column chromatography , impurity , chromatography , catalytic hydrogenation , organic chemistry , combinatorial chemistry , biochemistry
Pd-Catalyzed hydrogenation process has been developed to synthesize tetrahydrocurcumin from synthetic curcumin. Use of diphenyl sulphide as catalyst poison is crucial for lowering the activity of the catalyst and thus reduces impurity formation. The process avoids column chromatography to achieve good quality tetrahydrocurcumin in cost effective manner. All the prepared compounds are characterized by FT-IR, 1H NMR, mass and HPLC techniques.