Open AccessApplication of Mathematical Models in Drug Release Kinetics of Cyanocobalamine Fast Dissolving Sublingual Film
Author(s) -
Adil Patel,
Ami Kalsariya,
Srushti Patel,
C. K. Patel,
Srushti Patel
Publication year - 2021
Publication title -
asian journal of medicine and health
Language(s) - English
Resource type - Journals
ISSN - 2456-8414
DOI - 10.9734/ajmah/2021/v19i830360
Subject(s) - dissolution , kinetics , phosphate buffered saline , chromatography , drug , materials science , chemistry , gelatin , dosage form , chemical engineering , pharmacology , organic chemistry , medicine , engineering , physics , quantum mechanics
The aim of present work is to determine and analyse the kinetics of drug release from the fast dissolving sublingual by employing various mathematical models. A study was done with Cyanocobalamine fast dissolving sublingual films, 1.5 mg/film by employing solvent casting technique using dehydrated banana starch and Gelatin. The in-vitro drug release profile was carried out in pH 6.8 phosphate buffer (900 mL) using USP dissolution apparatus I (Basket) at 50 rpm for 20 mins. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile of Cyanocobalamine fast dissolving sublingual films.