Open AccessAntidiarrhoeal Studies of Methanol Leaf Extract of Cassia sieberiana Dc in Wistar Albino Rats
Author(s) -
Jude Nwaogu,
Ibrahim Babangida Abubakar,
Esther Omolade Olaosebikan
Publication year - 2021
Publication title -
asian journal of biochemistry, genetics and molecular biology
Language(s) - English
Resource type - Journals
ISSN - 2582-3698
DOI - 10.9734/ajbgmb/2021/v7i330177
Subject(s) - antidiarrhoeal , phytochemical , traditional medicine , cassia , methanol , terpenoid , medicine , chemistry , botany , biology , castor oil , biochemistry , organic chemistry , alternative medicine , traditional chinese medicine , pathology
Aim: This study was aimed at evaluating the antidiarrhoeal effect methanol leaf extract of Cassia sieberiana.
Methodology: The leaf extract of Cassia sieberiana was obtained by extraction using methanol and subjected to phytochemical screening using standard methods. The anti-diarrhoeal effect of methanol leaf extract of Cassia sieberiana DC was investigated in Wistar Albino rats.
Results: The result of phytochemical screening revealed the presence of saponins, tannins, phenols, terpenoids, cardiac glycosides, steroids, flavonoids and anthraquinoes. The methanol extract significantly (P<.05) reduced the number of unformed faeces in castor oil induced diarrhoea in the rats. It also significantly (P<.05) reduced the gastrointestinal transit of activated charcoal as well as enteropooling in the rats used for the experiment was significantly reduced (P<.05) in the groups treated with 500 mg/kg and 750 mg/kg.
Conclusion: Based on the findings of this research, the methanol leaf extract of Cassia sieberiana possess anti-diarrheal activity and therefore validates its use in traditional medicine for the treatment of diarrhoea.