Open AccessBiochemical and Histopathological Studies on the Efficacy of Camel Milk and Urine against Alloxan Induced Diabetic Rats
Author(s) -
Abdullahi Muhammad Labbo,
Sadeeq Muhammad Sheshe,
Haris Ja’afar Bello,
Zulkallaini Shehu,
Zainab Hassan Bello
Publication year - 2020
Publication title -
asian journal of biochemistry, genetics and molecular biology
Language(s) - English
Resource type - Journals
ISSN - 2582-3698
DOI - 10.9734/ajbgmb/2020/v3i430093
Subject(s) - camel milk , urine , metformin , medicine , alloxan , diabetes mellitus , endocrinology , high density lipoprotein , lipid profile , low density lipoprotein , alanine aminotransferase , cholesterol , chemistry , food science
Background: Camel urine has been extensively used for the treatment of diseases including cancer. However, it uses in the management of diabetes complication has not been explored.
Aim: Present study aimed to access the effect of camel milk and urine on biochemical parameters and histopathological alterations of the liver in alloxan induced diabetic rats.
Methodology: Twenty-five male albino rats were divided into five groups; group 1 served as the Nondiabetic (NDC), group 2 as Diabetic control (DC), group 3, 4 and 5 are animals treated with camel milk (DCM), camel urine (DCU) and metformin (DM) respectively. The treatment was for twenty-one days. The protective role of camel milk and urine was evaluated by determining biochemical parameters and also by studying the histopathological alterations of the liver.
Results: The results indicate a significant increase (P<0.05) in aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total protein (TP) in DC rats compared to NDC. However, nosignificant difference was observed in the serum level of alkaline phosphate (ALP) between NDC and DC groups (P <0.05). Treatments of diabetic rats with either camel milk, camel urine or metformin significantly (P <0.05) serum activities of AST, ALT and TP. The results of lipid profile show that pretreatment of diabetic rats with camel milk or urine significantly (P<0.05) decreases serum levels of triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) compared to diabetic control group compared to DC group. Moreover, high density lipoprotein cholesterol (HDL-C) increased remarkably in the groups treated with CM, CU and metformin respectively. Histopathological studies of the liver revealed that all the severe endocrine changes in the endocrine part and localized necrosis present in DC are absent in the Diabetic treated with camel milk (DCM), Diabetic treated with camel urine (DCU) and Diabetic treated with metforming (DM) groups.
Conclusion: Treatment with camel milk or urine has the potential to delay the onset of diabetic complications.