Open AccessSynthesis, Characterization, Swiss ADME and Antimicrobial Activity of Copper (II) Complex with 2-Sulfanilamidopyrimidine: Through DFT Spectroscopic with Profound Biological Implications
Author(s) -
Mohd. Washid Khan,
Rakesh Mishra,
Bhavesh Patel,
Shradha Patel,
Sujit Gupta,
Souvik Sen
Publication year - 2021
Publication title -
asian journal of applied chemistry research
Language(s) - English
Resource type - Journals
ISSN - 2582-0273
DOI - 10.9734/ajacr/2021/v9i130203
Subject(s) - antimicrobial , chemistry , copper , combinatorial chemistry , imine , adme , biological activity , fourier transform infrared spectroscopy , benzimidazole , organic chemistry , biochemistry , catalysis , physics , quantum mechanics , in vitro
Sulphadiazine and their copper metal complexes are dexterous ligands, which are condensation products of primary amines with carbonyl compounds gaining importance day by day in the present scenario. Spectral characterization and examination of the potential antimicrobial and antioxidant activity of the synthesized complex were performed. The imine Cu(II) complex is characterized by FTIR and UV/Vis spectroscopy. The Stoichiometric M:L ratio was determined by Joe and Jones method. These compounds and their copper metal complex are very important in various biological systems and their medicinal and pharmaceutical fields. Schiff foundations show beneficial natural functions such as anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, and antiglycation. The present review summarizes information on the diverse biological activities and also highlights the recently synthesized numerous Schiff bases and their metal complex as potential bioactive core.