Open AccessANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF PLANT SIDA CORDATA IN CARRAGEENAN-INDUCED PAW EDEMA IN RATS
Author(s) -
Prajakta P Shinde,
Shahu D Khule,
Sneha Sonawane,
Suvarna Shelke
Publication year - 2021
Publication title -
journal of pharmaceutical and scientific innovation
Language(s) - English
Resource type - Journals
ISSN - 2277-4572
DOI - 10.7897/2277-4572.102205
Subject(s) - carrageenan , traditional medicine , anti inflammatory , pharmacology , antioxidant , inflammation , medicine , antifungal , edema , medicinal plants , chemistry , immunology , biochemistry , dermatology
Since ancient times in India several medicinal plants are in use for clinical practices. Inflammation is a process through which the body's white blood cells and the things they make protect body from infection from outside invaders, such as bacteria and viruses. Currently many of the plant’s species have been reported effective as an Anti-inflammatory, but only a few of them have been investigated. Currently many drugs are available to control the inflammation but has several adverse effects. The plant Sida Cordata was reported to have several activities such as Antioxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, in ayurvedic system of medicine. This study was undertaken to investigate the anti-inflammatory activity of Methanolic extract of Sida Cordata. The methanolic extract of Sida Cordata used for treatment of Carrageenan-induced Rat paw Oedema model with the predefined dose as reported. The experimental groups with higher dose of methanolic extract (200 mg/kg) exhibited a significant anti-inflammatory effect after 2 hr. (p<0.01); based on the observation, the activity was favorable, which is nearly equal to that of the standard drug Indomethacin (10 mg/kg). The methanol extract (200 mg/kg) shows the maximum percentage of inhibition of inflammation 27.06 %. The standard drug indomethacin shows 33 % inhibition.