Open AccessEFFECT OF TRUSHNADI LOHA ON HYPER LIPIDAEMIA: A CLINICAL STUDY
Author(s) -
Kakarla Subbarao,
M L Naidu,
K. Gayathri
Publication year - 2013
Publication title -
international journal of research in ayurveda and pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2277-4343
pISSN - 2229-3566
DOI - 10.7897/2277-4343.04521
Subject(s) - physical medicine and rehabilitation , medicine , traditional medicine
Hyperlipidemia is a rise in plasma cholesterol, triglycerides or both. It is a major lifestyle disorders in affluent societies, which has been referred to as the santarpanajanya vyadhi (over nutrition) in the classical texts. A herbomineral formulation named trushanadiloha that has been advocated by Acharya Yogaratnakara for the management of medoroga / hyperlipidemia selected for open labeled randomized trial and was carried out on 54 patients suffering from hyperlipidemia. Of the 54 patients, 50 completed the entire course of treatment. The result of the study on serum cholesterol, serum low density lipoproteins, serum very low density lipoproteins, and triglycerides with trial drug found tube extremely statistically significant (p <0.0001). The response of the drug was extremely statistically significant on moderate improvement of clinical features. (Ch 49, DF 2, p < 0.0001). The response of the drug on Body weight, Body weight index, Body surface area was extremely statistically significant (p < 0.0001). Increase in Ponderal index was statistically significant (p > 0.0180). 48 % (24 out of 50 patients) increase of serum high density lipoproteins was observed. The drug decreased total lipid atherogenisity index, which was extremely statistically significant (p < 0.0001). The drug was proved as free radical scavenger and powerful anti- oxidant, anti-hyperglycemic, anti- obese and anti- hyperlipidemic by conducting in- vitro and in-vivo preclinical studies