Open AccessABHRAK BHASMA MEDIATED ALTERATIONS IN LIVER AND KIDNEY FUNCTIONS IN MALE ALBINO RATS DURING CARBON TETRACHLORIDE INDUCED TOXICITY
Author(s) -
Teli Parashuram,
Chougule Priti,
Jadhav Jaywant,
K. Aruna
Publication year - 2013
Publication title -
international journal of research in ayurveda and pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2277-4343
pISSN - 2229-3566
DOI - 10.7897/2277-4343.04514
Subject(s) - carbon tetrachloride , toxicity , kidney , ccl4 , carbon tetrachloride poisoning , chemistry , pharmacology , liver toxicity , toxicology , biology , medicine , organic chemistry
Abhrak bhasma, an Ayurvedic drug used against many diseases including hepatitis. In present study various doses of abhrak bhasma (10, 20, 30 and 40 mg/kg body wt) were tested for hepatoprotective efficacy against carbon tetrachloride (CCl4) intoxicated liver and kidney functions in male albino rat. Administration of CCl4 to the normal rat increased serum levels of AST, ALT, ALP and bilirubin indicated acute damage. Abhrak bhasma treatment counteracted the action of CCl4 on liver and kidney functions. With the administration of increasing doses of abhrak bhasma all activities were dropped progressively and significantly at 40 mg dose as compared with silicate control. Conjugation metabolism and excretion of bilirubin were improved with increasing doses of abhrak bhasma suggesting dose dependent protection of all metabolic steps in bilirubin metabolism. Also CCl4 induced acute toxicity increased serum urea and creatinine content, which was progressively controlled by increasing abhrak bhasma doses. The findings of this study indicated that abhrak bhasma exert dose dependent protective effects in liver and kidneys functions against CCl4 induced toxicity in albino rat