Open AccessSCREENING OF FREE RADICAL SCAVENGING ACTIVITY OF AROGYAVARDHINI VATI
Author(s) -
R S Sarashetti,
C C Simpi,
Nefthi Sandeep,
Veena Kanthi
Publication year - 2013
Publication title -
international journal of research in ayurveda and pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2277-4343
pISSN - 2229-3566
DOI - 10.7897/2277-4343.04421
Subject(s) - scavenging , chemistry , traditional medicine , medicine , biochemistry , antioxidant
Free radicals are the main cause for the pathogenesis of disease. Considering present day’s lifestyle oxidant stress is more on everyone. So anti-oxidants are in much demand worldwide. Only Ayurveda is science of life which has provided a rational basis for such thoughts and active medicines. Arogyavardhini vati is a potent formulation explained in rasashastra for maintaining health. An attempt was made to establish scientific evidence for anti-oxidant property of Arogyvardhini vati. Oxidative stress was induced in albino rats with carbon tetra chloride in all the groups except control. In control group only oxidative stress was induced without drugs. In test group three different concentration of Arogyvardhini vati (10 mg / ml, 20 mg / ml and 50 mg / ml) was administered. In standard group vitamin-c was used. Lipid peroxidation, Glutathione, Catalase Amylase, superoxide dismutase levels were estimated for four days. In an antioxidant assay Arogyvardhini vati 10 mg / ml and 20 mg / ml showed the significant reduction of malondialdehyde concentration and significant improvement in Glutathione, superoxide dismutase, Catalase Amylase activity. Antioxidant activity of Arogyvardhini vati was comparable to that of standard. Arogyvardhini vati demonstrated significant anti-oxidant activity compared to standard and control. This scientific data has given further scope for study in a larger samples and clinical study