Open AccessWITHANIA SOMNIFERA PROTECTS THE HAEMATOLOGICAL ALTERATIONS CAUSED BY SODIUM ARSENITE IN CHARLES FOSTER RATS
Author(s) -
Arun Kumar,
Mohammad Ali,
Ranjit Kumar,
S. Suman,
H T Satish Kumar,
Anirudh Nath,
Jatinder Singh,
Dhyanendra Kumar
Publication year - 2013
Publication title -
international journal of research in ayurveda and pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2277-4343
pISSN - 2229-3566
DOI - 10.7897/2277-4343.04405
Subject(s) - withania somnifera , sodium arsenite , traditional medicine , biology , pharmacology , chemistry , medicine , pathology , arsenic , alternative medicine , organic chemistry
This study was carried out to investigate the therapeutic role of the ethanolic extract of Withania somnifera on Sodium Arsenite induced haematological alterations in rats. Oral administration of sodium arsenite at the dose of 8 mg/kg body weight daily caused haematological alterations in rats as manifested by the significant decrease in RBC’s count, Haemoglobin percentage, Haematocrit, Mean Cell Volume of RBC’s (MCV), Mean Cell Haemoglobin (MCH), Mean Cell Haemoglobin Concentration (MCHC) and White Blood Cell Count (WBC’s) as compared with control. The Lipid peroxidation also showed elevated levels in comparison to control. But, after oral administration of ethanolic extract of Withania somnifera at the dose of 200 mg/kg body weight daily for 30 days to Sodium Arsenite pretreated rats there was an increase in the haematological parameters as well as lipid peroxidation levels decreased significantly. The study reveals that ethanolic extract of Withania somnifera possesses protective effect against haematological alterations caused by arsenic induced toxicity.Keywords