Open AccessTOXICOLOGICAL STUDIES AND CYTOTOXIC ACTIVITY OF ETHANOL AND ETHYL ACETATE EXTRACTS OF TECOMARIA CAPENSIS LEAVES
Author(s) -
Tamil E Jothi,
Vimala G Devi,
Ch Vamsi Anil Krishna,
V. Suba
Publication year - 2013
Publication title -
international journal of research in ayurveda and pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2277-4343
pISSN - 2229-3566
DOI - 10.7897/2277-4343.04324
Subject(s) - ethyl acetate , ethanol , cytotoxic t cell , traditional medicine , chemistry , biochemistry , in vitro , medicine
In the present study ethyl acetate and ethanol extracts of leaves of Tecomaria capensis was screened for cytotoxic activity. The cytotoxic activity was performed by two models. One was short term cytotoxicity and another was long term cytotoxicity. In short term cytotoxicity assay Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC) cell lines were used and for long term L929 cell lines (Lungs fibroblast) were used. In both methods ethyl acetate and ethanol extracts showed protective action against the cell lines. Comparing both extracts, ethanol extract has shown better cytotoxic activity than the ethyl acetate extract and in comparison of standard both extracts have moderate cytotoxic activity