Open AccessSYNTHESIS AND EVALUATION OF ANTIANGIOGENIC AND ANTICANCER PROPERTIES OF NOVEL OXADIAZOLE ANALOGUES
Author(s) -
V. Girish,
N. D. Rekha,
V. Lakshmi Ranganatha,
S. Manjula,
Shaukath Ara Khanum
Publication year - 2014
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.0506101
Subject(s) - oxadiazole , chemistry , combinatorial chemistry , pharmacology , medicine , organic chemistry
Oxadiazole,a heterocyclic nucleus has attracted a wide attention of the chemist in search for the new therapeutic molecules. Out of its four possible isomers, 1, 3, 4-oxadiazole is biologically active, synthetically useful and widely exploited for various applications. Various biological activities are reported to be associated with 1, 3, 4-oxadiazoles. Encouraged by these reports the present study has been undertaken. The newly synthesized compounds were confirmed from IR, 1H NMR and mass spectral data. All the synthesized compounds were subjected for anti angiogenesis as well as anticancer activity. Compounds 7b and 10d showed very good anti angiogenesis and anticancer activity compared to all other analogues in the series