Open AccessHEPATOPROTECTIVE AND ANTI-HEPATOTOXIC ACTIVITIES OF AQUEOUS LEAF EXTRACT OF TACAZZEA BARTERI AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS
Author(s) -
Obioha Mary Quinette Uru,
Ilodigwe Emmanuel Emeka,
Ajaghaku Daniel Lotanna,
Umeokoli Blessing Ogechukwu
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04913
Subject(s) - carbon tetrachloride , traditional medicine , aqueous extract , chemistry , ccl4 , pharmacology , biology , medicine , organic chemistry
The hepatoprotective and anti hepatotoxic effect of Tacazzea barteri was evaluated using carbon tetrachloride (CCL4) induced hepatotoxicity. For the hepatoprotective study, the animals were treated with 200, 400 and 600 mg/kg of T. barteri extract for 7 days prior to the intra peritoneal injection of 1 ml/kg of carbon tetrachloride while for the anti hepatotoxic study; 1 ml/kg of carbon tetrachloride was administered via intra peritoneal route before treatment (2 days). Blood samples were collected from the animals before and after treatment and serum biochemical parameters (AST, ALT, ALP, Bilirubin and Albumin) were determined. The extract showed significant (p < 0.01) reduction in the carbon tetrachloride induced elevation of ALT, AST, ALP and Bilirubin and a significant (p < 0.01) increase in carbon tetrachloride induced suppression of Albumin induction in both models. Histological photomicrographs of liver sections of the untreated groups showed high cellular damage while no visible histological damages were noticed in the extract treated groups in the hepato-protective model while mild cellular damage was noticed in the anti-hepatotoxic model. The extract not only showed protection of the liver cells against CCL4 hepatotoxin but also showed reversal of hepatic damage cause by CCL4. This study justifies the folkloric use of T. barteri in the treatment of liver diseases