Open AccessSYNTHESIS AND EVALUATION OF OXAZOLIDINONES HAVING BENZO THIAZINEN MOIETIES AS ANTIMICROBIAL AND ANTI-INFLAMMATORY AGENTS
Author(s) -
Jennifer Fernandes,
Pankaj Kumar,
Abhishek Kumar
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04853
Subject(s) - chemistry , antimicrobial , acetic anhydride , candida tropicalis , candida albicans , sodium azide , sodium hydride , cryptococcus neoformans , sulfonyl , maleic anhydride , organic chemistry , microbiology and biotechnology , alkyl , yeast , biochemistry , biology , polymer , copolymer , catalysis
Phenyl oxazolidinones were prepared from R-glycidyl butarate and Para bromo aniline, further (3-(4-bromophenyl) methylene oxazolidine-5yl) and substituted benzothiazinen was refluxed resulted in oxazolidinones benzothiazinen moieties. Treatment of these oxazolidinones benzo thiazinen moieties with methane sulfonyl gives its sulphonates on further treatment with sodium azide and tri phenyl phosphine in acetic anhydride gives acetamide derivatives. Further synthesized compounds were characterized by IR, H NMR1 and Mass spectral studies. The synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against, Candida albicans and Aspergillus niger. The synthesized compound was screened for their anti-inflammatory activity by carrageenan induced paw-edema method