Open AccessFORMULATION AND IN VITRO EVALUATION OF OMEPRAZOLE FAST DISSOLVING TABLETS
Author(s) -
Soumya Missula,
Y. A. Chowdary,
Gayathri Pedamallu,
Kondempudi Sai Krishna Mohan,
Mellacheruvu Mohana krishna
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04833
Subject(s) - omeprazole , in vitro , dissolution , chemistry , pharmacology , chromatography , medicine , biochemistry , organic chemistry
Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), Gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease (LPR) and Zollinger-Ellison syndrome. The present study deals with the formulation of omeprazole fast dissolving tablets utilising cross linked alginic acid and calcium silicate as super disintegrates and a total of 8 formulation batches were prepared. All the pre compression and post compression parameters are studied and the results comply with in the limits. In vitro dissolution studies explained that the optimised F7 formulation with super disintegrants Cross linked alginic acid at low ratio and Calcium silicate at high ratio showed a cumulative release of 99.6 % of drug at the end of 12 minutes and also exhibited first order kinetics with Higuchi mechanism of drug release