Open AccessNANOSUSPENSION: RECENT TRENDS AND TECHNOLOGIES
Author(s) -
Priyanka Ahlawat,
Anupama Diwan,
Ramandeep Singh
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04702
Subject(s) - solubility , nanotechnology , materials science , biochemical engineering , pipeline (software) , process engineering , chemistry , computer science , engineering , organic chemistry , programming language
With the advent of modern technologies, a large number of drugs have been discovered which have a better efficiency but their clinical application is restricted due to poor water solubility. Nearly 40 % of the drugs in the pipeline and around 60 % of compounds coming directly from synthesis have poor solubility. Poor water solubility has become a leading challenge for the formulation of these compounds. Poor solubility is generally associated with poor bioavailability. Nanosuspension has the potential to overcome this issue. Change of materials into the nanodimension dramatically changes its physical properties. Drug nanocrystals are crystals with a size in the nanometer range (mean diameter < 1000 nm). This review article outlines the various pharmaceutical advantages of nanosization industrially relevant production technologies available currently (high pressure homogenization, pearl milling) with advantages and disadvantages of each and the various dosage forms developed using nanocrystals. The nanosuspension products in the market / pipeline will be briefly reviewed and the advantages of these as compared to traditional products would be highlighted