Open AccessREPEATED DOSE 28-DAY ORAL TOXICITY STUDY OF RAW ARECA NUT EXTRACT IN RATS
Author(s) -
T S Lohith,
N. B. Shridhar,
S.M. Dilip,
Jayashree Pattar,
K. Suhasini
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04550
Subject(s) - areca , nut , traditional medicine , toxicity , medicine , toxicology , pharmacology , biology , structural engineering , engineering
The aqueous extract of raw areca nut extract was evaluated for the repeated dose 28-day oral toxicity effect on biochemical, haematological, feed consumption, body weight gain and histopathological parameters in rats. In repeated dose 28-day oral toxicity study, the doses administered orally were distilled water (control), 100, 250 and 500 mg/kg of raw areca nut extract for a period of 28 days. There was a significant increase (P<0.05) in AST, ALT and Cr of both male and female rats during the study period, but haematological parameters such as TEC, TLC, PCV and Hb concentration did not show any significant changes. Significant decrease (P<0.05) in feed consumption and body weight gain was also noticed. The histopathological changes of liver and kidney in rats indicate hepatotoxicity and mild degree of nephrotoxicity. Satellite high dose group administered with 500 mg/kg of raw areca nut extract showed normal in biochemical and haematological values, and architecture of the internal organs. This indicates that normal recovery of the animals after the treatment has been stopped