EVALUATION OF HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF ABUTILON INDICUM FOR ITS ANALGESIC AND SEDATIVE PROPERTY

The hydro alcoholic extract of aerial parts of Abutilon Indicum was tried for its efficacy as analgesic and sedative property. Several pain models namely Eddy’s hot plate, acetic acid induced writhing test, tail clip test and hot water immersion test were tried and for sedative property actophotometer test was performed. As the extract has shown very significant (P˂0.01) result in Eddy’s hot plate, acetic acid induced writhing test and hot water immersion test hence it is believed that the extract has certain central and peripheral analgesic property which may be mediated either by closing Na+ or/and Ca2+ channels or by facilitating chloride Cl- influx by acting on GABAA receptor. As the extract has significantly reduced loco motor activity hence the mechanism of action of the extract is believed to be mediated by opening of Cl- channel, indicating that the extract may have GABA mimetic or facilitating effect. As following the administration of the extract no straub reaction was observed hence may be in future it will gain more popularity to be used as a substitute for narcotics to treat pain and also as a good sedative