Open AccessDESIGN AND IN VITRO EVALUATION STUDIES OF DICLOFENAC SODIUM FLOATING MATRIX TABLETS BY MELT GRANULATION TECHNIQUE
Author(s) -
Subramaniyan Chandra,
Sreeraj Gopi,
Biyogo ogetii alex,
Omarbakri nasreidin elsayed,
Oleti Chandra sai pavan
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04531
Subject(s) - friability , granulation , diclofenac sodium , angle of repose , ethyl cellulose , sodium bicarbonate , dissolution , chromatography , methyl cellulose , materials science , chemistry , nuclear chemistry , chemical engineering , cellulose , composite material , polymer , organic chemistry , engineering
The purpose of this study was to formulate diclofenac sodium floating matrix drug delivery system by melt granulation technique. These tablets were developed to prolong gastric residence time and increase its bio availability. The diclofenac sodium tablets of 100mg were developed by using different bees wax combinations which are prepared by melt granulation technique by using polymers such as Hydroxy propyl methyl cellulose(HPMC K15M), ethyl cellulose, bees wax alone or in combination with cetyl alcohol, sodium bicarbonate as a gas generating agent and other standard excipients. The prepared granules are subjected to pre compression studies such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio. The optimized formulation produced monolithic tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies, floating lag time indicates that formulations F6 exhibited good and controlled drug release