Open AccessA SIMPLE, EFFICIENT AND SOLVENT FREE ONE POT SYNTHESIS OF 3, 3 DIHETEROAROMATIC OXINDOLE
Author(s) -
S. M. Ali,
Maqdoom Farooqui,
Sayyad Sultan,
Maulana Azad,
Rafiq Zakaria
Publication year - 2016
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04431
Subject(s) - oxindole , simple (philosophy) , combinatorial chemistry , chemistry , solvent , mathematics , organic chemistry , philosophy , catalysis , epistemology
Formic acid catalyzed, single step and environmentally friendly process for synthesis of 3, 3- diheteroaromatic oxindole derivatives is described. This adopted protocol for Friedel- Crafts substitution reaction has the advantage of reusability of the catalyst, high yields and ease of separation of pure products