Open AccessCLINICAL EVALUATION OF KODIPAVALA CHUNNAM IN THE TREATMENT OF INFECTIVE HEPATITIS, DRUG INDUCED HEPATITIS AND ALCOHOLIC HEPATITIS
Author(s) -
V. Velpandian,
M Pitchiahkumar,
I S Gnanavel,
N Anbu,
A M Abdul Kadher
Publication year - 2016
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04430
Subject(s) - alcoholic hepatitis , medicine , hepatitis , drug , virology , gastroenterology , alcoholic liver disease , pharmacology , cirrhosis
The present clinical study was carried out to validate the efficacy and safety of Siddha Herbo- mineral formulation ‘Kodipavala Chunnam’ in the treatment of Infective hepatitis, Drug induced hepatitis and Alcoholic hepatitis. Open clinical trial was conducted in 40 patients with these three categories of hepatitis in Arignar Anna Govt.Hospital of Indian Medicine and Homeopathy, Chennai. The trial drug Kodipavala Chunnam was administered in all the patients at the dose of 100 mg to 200 mg thrice a day with honey depending on severity. The clinical improvement shown by cases treated with Kodipavala Chunnam was more quick and significant. Before drug administration to patients it was observed that a significant increase in the levels of serum bilirubin ALT, AST, SAP, GGT and globulin. Elevated levels of these parameters are indicative of functional impairment of liver. Administration of KPC remarkably (P<0.001) restored elevated serum bilirubin ALT, AST, SAP, GGT and globulin towards normal value. Overall results revealed that out of 40 patients 10 patients had excellent relief, 26 had good relief, 3 cases showed satisfactory result and only one case showed fair response. The results clearly have shown that the Kodipavala Chunnam treatment to the jaundice therapy helped in cutting down the course of the disease and relieving jaundice earlier. There were no new or unexpected safety events noticed during the course of the treatment