Open AccessEVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF ABUTILON INDICUM
Author(s) -
Sharma Sat ish Kumar,
Sharma Seshasai Marella,
Vipin Saini,
Sharmistha Mohapatra
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04350
Subject(s) - abutilon , traditional medicine , biology , chemistry , botany , medicine , weed
The present study was undertaken to evaluate the anti-ulcer properties of Abutilon indicum (AI). Ethanolic (AIE) and aqueous extracts (AIA) of AI were studied for their ability to inhibit the gastric lesions in pylorus ligation, aspirin and alcohol induced ulcer models in rats. In addition their effects on pH, wall mucus, total acidity and gastric acid output were recorded. The test drugs in the dose of 200 mg/kg were administered twice daily orally at 10:00 h and 16:00 h respectively for five days for gastro protective studies. Ranitidine was used as reference drug. Ethanolic and aqueous extracts of Abutilon indicum significantly inhibited the gastric lesions induced by pylorus ligation, aspirin and alcohol. The gastric volume and total acidity were found to be significantly reduced while the gastric pH and mucus contents were found to be increased as compared to control group. The present findings suggest that the antiulcer properties of Abutilon indicum may be due to its effect on both offensive and defensive factors. These results support the ethno medical uses of Abutilon indicum in the treatment of ulcer