Open AccessORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM: AN OVERVIEW
Author(s) -
Kushal Modi,
Monali Modi,
Durgavati Mishra,
Panchal Mittal,
Umesh Sorathiya,
Pragna K. Shelat
Publication year - 2013
Publication title -
international research journal of pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2230-8407
DOI - 10.7897/2230-8407.04312
Subject(s) - drug delivery , drug , immediate release , controlled release , pharmacology , medicine , chemistry , organic chemistry
Oral drug delivery is the most preferred and convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral controlled release drug delivery systems. Controlled release drug delivery system works on many different mechanisms to control the release rate of drugs. Various mechanisms like osmotic pressure, matrix system, reservoir system, altered density system etc. have been utilized as formulation approaches. The present article contains brief review on various formulation approaches for controlled release drug delivery system