MANAGEMENT OF THALASSEMIA

The thalassemias are a heterogeneous group of genetic disorders characterized by decreased or absent production of one or more globin chains that make up a hemoglobin molecule. Each hemoglobin molecule is composed of four globin chains; normally two from thea family and two from the b family of globin chains. Each hemoglobin molecule also has a heme group containing iron. The thalassemia is broadly categorized according to the globin chain that is defective. The common signs and symptoms of thalassemic diseases include pale skin, retarded growth and puberty, anemia, enlarged spleen, and increased susceptibility to infections. The present work summarizes etiology, complication issues, management and prognosis of thalassemias