Open AccessEosinophilic esophagitis
Author(s) -
Saurabh Kedia
Publication year - 2015
Publication title -
tropical gastroenterology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2320-5792
pISSN - 0250-636X
DOI - 10.7869/tg.277
Subject(s) - eosinophilic esophagitis , eosinophilia , dysphagia , medicine , gastroenterology , pathological , esophagus , esophagitis , esophageal disease , reflux esophagitis , disease , reflux , surgery
Eosinophilic esophagitis (EoE) is a clinico-pathological entity characterised by symptoms of esophageal dysfunction and eosinophilia on esophageal mucosal biopsies in the absence of other causes of esophageal eosinophilia. It is a chronic inflammatory condition of esophagus often characterized by refractory reflux symptoms in children and dysphagia in adults. It occurs as a result of Th2 inflammatory response to environmental triggers (food antigens) in genetically predisposed individuals. The diagnostic criteria include symptoms of esophageal dysfunction, esophageal eosinophilia (> 15/hpf), and a PPI trial (persistent eosinophilia after 8 weeks of PPI). Mainstay of treatment at present is topical steroids and dietary therapy. Maintenance treatment should be considered to prevent long term complications.