Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India | Zendy

Sreedhar Chinnaswamy | Zendy

Open Access

Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India

Author(s) -

Sreedhar Chinnaswamy

Publication year - 2014

Publication title -

tropical gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 2320-5792

pISSN - 0250-636X

DOI - 10.7869/tg.187

Subject(s) - genotype , ribavirin , single nucleotide polymorphism , hepatitis c virus , snp , minor allele frequency , hepatitis c , medicine , allele , virology , hepacivirus , biology , immunology , gastroenterology , genetics , virus , gene

IL28B gene polymorphisms have been associated with treatment-response (sustained virological response, SVR) in genotype 1 hepatitis C virus (HCV)-infected patients, but only with early phase of viral decline (rapid virological response, RVR) with genotype 3 HCV-infected patients. Association between IL28B variants and SVR in genotype 3 HCV- infected patients is unclear. Our study aimed to replicate the association of IL28Bsingle nucleotide polymorphism (SNP) rs8099917 with SVR and to validate its association with RVR in genotype 3 HCV-infected patients.

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