Open AccessAssociation of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India
Author(s) -
Sreedhar Chinnaswamy
Publication year - 2014
Publication title -
tropical gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2320-5792
pISSN - 0250-636X
DOI - 10.7869/tg.187
Subject(s) - genotype , ribavirin , single nucleotide polymorphism , hepatitis c virus , snp , minor allele frequency , hepatitis c , medicine , allele , virology , hepacivirus , biology , immunology , gastroenterology , genetics , virus , gene
IL28B gene polymorphisms have been associated with treatment-response (sustained virological response, SVR) in genotype 1 hepatitis C virus (HCV)-infected patients, but only with early phase of viral decline (rapid virological response, RVR) with genotype 3 HCV-infected patients. Association between IL28B variants and SVR in genotype 3 HCV- infected patients is unclear. Our study aimed to replicate the association of IL28Bsingle nucleotide polymorphism (SNP) rs8099917 with SVR and to validate its association with RVR in genotype 3 HCV-infected patients.