Open AccessFrequency and factors associated with increased small intestinal permeability in patients with portal hypertension
Author(s) -
Ajesh Goyal
Publication year - 2013
Publication title -
tropical gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2320-5792
pISSN - 0250-636X
DOI - 10.7869/tg.117
Subject(s) - lactulose , cirrhosis , gastroenterology , ascites , medicine , spontaneous bacterial peritonitis , portal hypertension , mannitol , intestinal permeability , biology , biochemistry
Cirrhosis with portal hypertension (PHT) may be associated with increased small intestinal permeability (SIP), predisposing to malnutrition and bacterial translocation causing septicaemia, endotoxaemia and spontaneous bacterial peritonitis. However, data on SIP in extrahepatic portal venous obstruction (EHPVO), in which PHT occurs without hepatic dysfunction, are scanty. Such studies would help to know the effect of PHT on SIP independent of hepatic dysfunction; hence, we undertook this study.